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J&J, Bavarian Nordic start clinical tests in Ebola vaccine race

REUTERS     by Ben Hirschler                              Jan. 6, 2015
LONDON --Johnson & Johnson has started clinical trials of its experimental Ebola vaccine, which uses a booster from Denmark's Bavarian Nordic, making it the third such shot to enter human testing.

The initiation of the Phase I study in Britain, which had been expected about now, marks further progress in the race to develop a vaccine against a disease that has killed more than 8,000 people in West Africa since last year.

Two other experimental vaccines, one from GlaxoSmithKline and a rival from NewLink and Merck, are already in clinical development. However, the J&J vaccine offers a different approach, since it involves two separate injections.

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http://www.reuters.com/article/2015/01/06/us-health-ebola-vaccine-j-j-idUSKBN0KF0HH20150106

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Ebola: as ZMapp stocks run out doctors turn to alternative treatments

THE GUARDIAN by                                 Jan, 5, 2015
LONDON --Even at the Royal Free hospital in London, the lead UK specialist centre for Ebola, doctors have limited options for treating their patients. In the end, survival may depend more on the strength of an individual’s immune system than anything medical science is currently able to do.

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Save the Children probe how UK nurse contracted Ebola

BBC                                                                                                   Jan. 5, 2015

The charity Save the Children has said "no stone will be left unturned" in its investigation into how a British nurse working at an Ebola treatment centre contracted the disease.

 Pauline Cafferkey was diagnosed after returning to Glasgow a week ago. She had been working with the charity in Kerrytown, Sierra Leone.

Ms Cafferkey is critically ill in a north London hospital after her condition worsened in recent days.

Save the Children's Sierra Leone Director Rob MacGillivray told the BBC the charity would carry out a special investigation over and above its routine reviews....

He said the investigation would look at how protective equipment is used, and at person-to-person contact both inside and outside the Kerrytown treatment centre where the nurse worked.

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http://www.bbc.com/news/uk-30677619

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Ebola in the UK: Infected nurse Pauline Cafferkey in 'critical' stage of treatment

THE INDEPENDENT by Kashmira    Gander            Jan. 1, 2015

Pauline Cafferkey, the British nurse who contracted Ebola in Sierra Leone, is entering a “critical” stage of her recovery.

The nurse from Glasgow is being treated with an experimental anti-viral drug and blood from a survivor of the virus inside a quarantine tent at the Royal Free Hospital in north London, her doctor has said.

Dr Michael Jacobs said Ms Cafferkey was being treated with convalescent plasma taken from the blood of a recovered patient and an experimental anti-viral drug which is “not proven to work”.

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http://www.independent.co.uk/news/uk/home-news/ebola-in-the-uk-infected-nurse-pauline-cafferkey-in-critical-stage-of-treatment-9952904.html

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Ebola screening to be reviewed after doctor attacks ‘inadequate’ measures

THE GUARDIAN  by and              Dec. 31, 2014
LONDON--Public HealthEngland has vowed to review its Ebola screening measures after they were branded “utterly illogical” by an NHS doctor who returned from Africa with the Scottish nurse who has contracted the virus.

Public Health England said it would review its procedures, but defended its guidance as being in line with other organisations who have sent volunteers to Ebola-affected countries. Photograph: Amer Ghazzal/Rex

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Scottish government confirms Ebola case in Glasgow

UPDATE: Ebola Patient Is Moved to London, and 2 Others Are Tested in Britain

NEW YORK TIMES     by Alan Cowell                                                 Dec. 30, 2014

LONDON — A health worker who returned from West Africa and was found to have Ebola when she arrived home in Scotland was transferred on Tuesday to Britain’s designated treatment center for the disease in London. The authorities also reported that two more people were being tested for the virus.

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Ebola vaccine 'promising in African populations'

BBC     By Smitha Mundasad                                Dec. 22, 2014
The first-ever trial of an Ebola vaccine in Africa shows promising initial results, according to a report in the Lancet medical journal.

Scientists say it is a crucial step as other vaccines have shown lower levels of protection in African populations.

Tests involving Ugandan and American volunteers reveal the vaccine is so far safe and generates an immune response in both populations.

It provides reassurance for other trials currently underway, they say.

No proven vaccine exists to prevent people from getting the disease, though several trials are underway.

Researchers from the National Institutes of Health tested this experimental vaccine on healthy adults in Uganda, having first trialled it in the United States.

Dr Julie Ledgerwood, the lead researcher, said: "This is the first study to show comparable safety and immune response of an experimental Ebola vaccine in an African population.

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http://www.bbc.com/news/health-30577776

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Untested Ebola drug given to patients in Sierra Leone causes UK walkout

THE GUARDIAN           by Sarah Boseley                                                                    Dec. 22, 2014

FREETOWN, Sierra Leone -- Ebola patients at a treatment centre in Sierra Leone have been given a heart drug that is untested against the virus in animals and humans, a move that has been deemed reckless by one senior scientist and has prompted UK medical staff at the centre to leave.

                British health workers help an Ebola patient in Freetown, Sierra Leone. Photograph: Baz Ratner/Reuters

A 14-strong team of British doctors, nurses and paramedics stopped working at the Lakka treatment centre in Freetown because of their concerns over what they considered the experimental and potentially dangerous use of the drug, and other safety issues.

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Ebola fight sees Canadian Forces medical team deployed to Sierra Leone

CBC NEWS                                                                                                                     Dec.6, 2014

A Canadian Forces medical team left CFB Trenton in Ontario on Saturday en route to Britain, where they’ll undergo training before deploying to Sierra Leone as part of the effort to combat the Ebola outbreak, the military said.

Judith Bosse, (left to right), Assistant Deputy Minister at the Public Health Agency of Canada, Defence Minister Rob Nicholson, Health Minister Rona Ambrose and Dr. Gregory Taylor, Canada's Chief Public Health Officer, watch a nurse demonstrate how to remove protective clothing after treating a hypothetical Ebola patient. (Patrick Doyle/Canadian Press)

The Forces said about 40 nurses, doctors, physicians’ assistants, medics and support are to train alongside U.K. military personnel, and most of them will continue on to Sierra Leone by later this month.

The Canadian Forces team will be working at a British-built clinic in Sierra Leone treating local and international health care workers, who themselves have become infected in the course of treating Ebola patients from the general population.

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Nigerian and British Ebola volunteers fly into Liberia, Sierra Leone

Additonal  Nigerian and British health workers arrive in Liberia and Sierra Leone to help counter Ebola

(Two stories, scroll down)

REUTERS  by James Harding Giahyue and Umaru Fofana   Dec. 5, 2014
MONROVIA/FREETOWN --More than 175 Nigerian medics arrived in Liberia and Sierra Leone on Friday to join the fight against Ebola, the first of 600 volunteers promised by the regional giant which contained its own outbreak earlier this year.

An army medic teaches NHS staff how to dispose of potentially contaminated waste last month, before their deployment to Sierra Leone. Photograph: Simon Davis/AFP/Getty Images

The medics will boost weak local health systems that are also struggling to contain other preventable diseases as Ebola discourages people from going to clinics for fear of contracting the fever.

"This is the African spirit you are showing, this is the Nigerian spirit,” Nigeria's ambassador to Liberia, Chigozie Obi-Nnadozie, told 76 Nigerian medics who landed there.

Another 100 volunteers landed in Freetown, Sierra Leone. Months into the Ebola response, experts say they are still short of medical personnel to staff treatment centers.

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